The second approach is to define a custom style that you intend on using for your separator lines.
That way the Normal style remains unchanged and you won't have unintended consequences such as you see with the Footnote Separator line. Pick another style-perhaps Body Text-or create your own custom styles to use for your text. Besides the steps already outlined, there are two other ways around this problem.įirst, you can make a personal rule that you never use the Normal style for any of your regular document text. If these lines start showing some strange formatting characteristics, it is more than likely because you've made some changes in how the Normal style is defined. By default, the Footnote Separator and the other separator lines used by footnotes and endnotes all use the Normal style. While the above works just fine, there is one other thing you might want to keep in mind.
Click on the View Footnote Area radio button.If you have both footnotes and endnotes defined in your document, Word displays the View Footnotes dialog box.Display the References tab of the ribbon.(Click on the Draft View icon on the status bar of the document.) Make sure you are viewing your document in Draft view.
As a paragraph, you can easily format it just as you would any other paragraph. The footnote separator is inserted, automatically, by Word in its own paragraph. Jim would rather have the footnote separator align to the left column, rather than being indented. It lines up with the indented first line of a normal paragraph. Just above the footnotes and below the page's text is the footnote separator. The developed HPLC method was validated as per ICH-guidelines and can be used in drug testing labs for determination of quality of MCT in bulk and finished formulations.When Jim prints his document, the footnotes appear as they should at the bottom of each page. All the formed DPs were new and well separated with sufficient resolution. The final mass spectrometric conditions were optimized for better ionization of drug and DPs with optimum mass signal sensitivity. The developed HPLC method was transferred to LC–ESI–QTOF–MS/MS for identification of DPs. All these DPs were selectively separated using high-performance liquid chromatography (HPLC) with a stationary phase of Inertsil C₁₈ column (150 × 4.6 mm, 5 μm) and a mobile phase consisting of gradient mixture of 0.02% trifluoroacetic acid (TFA) and acetonitrile (ACN). The drug degraded extensively in acidic, basic as well as neutral hydrolytic conditions and seven degradation products (DPs) were formed. In the present study, MCT was subjected to forced degradation as per ICH guidelines. 525-531 ISSN: 0009-5893 Subject: acetonitrile, antagonists, drug evaluation, drugs, endothelin receptors, guidelines, high performance liquid chromatography, hypertension, ionization, mass spectrometry Abstract: Macitentan (MCT) is an endothelin receptor antagonist used for the treatment of pulmonary arterial hypertension. Gananadhamu Source: Chromatographia 2018 v.81 no.3 pp. Separation and Characterization of New Forced Degradation Products of Macitentan: A Dual Endothelin Receptor Antagonist Author: Mohit Thummar, Debasish Swain, S.
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